为了庆祝瑞贝卡(德拉彻饰)的50岁生日，艾比(波勒饰)邀请了闺蜜们一起到酒庄度假。杯觥交错间，虽然八卦和妙语如珠不断，她们仍无法忘却现实生活中的种种不确定，也开始对彼此的友谊及未来感到怀疑。
Amy Poehler
Abby
Maya Rudolph
Naomi
Rachel Dratch
Rebecca
Ana Gasteyer
Catherine
Paula Pell
Val
Emily Spivey
Jenny
Tina Fey
Tammy
Jason Schwartzman
Devon
Maya Erskine
Jade
Liz Cackowski
Lisa (Sommelier)
Cherry Jones
Lady Sunshine
Rachel Hamilton
Bartender
Brené Brown
Herself
Jon Glaser
TED Talk (voice)
