两个四年级学生乔治 和哈罗德，通过催眠术将霸道校长 变成了内裤队长。
Kevin Hart
George (voice)
Thomas Middleditch
Harold (voice)
Ed Helms
Captain Underpants / Mr. Krupp (voice)
Nick Kroll
Professor Poopypants (voice)
Jordan Peele
Melvin (voice)
Kristen Schaal
Edith (voice)
DeeDee Rescher
Ms. Ribble (voice)
Brian Posehn
Mr. Rected (voice)
David Soren
Tommy (voice)
Mel Rodriguez
Mr. Fyde (voice)
Susan Fitzker
Ms. Dayken (voice)
Lynnanne Zager
George's Mom (voice)
Tiffany Lauren Bennicke
Sad Girl (voice)
James Ryan
Mime (voice)
