影片改编自童书故事《好奇小猴乔治》，乔治是一只生性好奇的小猴子，因被一顶黄色的大草帽所吸引，从而来到了喧嚣的都市，本性善良与机智的他总是闯下无心之祸，但每一次都能化险为夷，让人捏把冷汗的同时不禁会心一笑。
Will Ferrell
Ted (Man with the Yellow Hat) (voice)
Drew Barrymore
Maggie (voice)
David Cross
Junior (voice)
Eugene Levy
Clovis (voice)
Joan Plowright
Ms. Plushbottom (voice)
Dick Van Dyke
Mr. Bloomsberry (voice)
Frank Welker
George (voice)
Ed O'Ross
Ivan (voice)
Michael Chinyamurindi
Edu (voice)
Michael Sorich
"Seen It" Cab Driver (voice)
Billy West
Manager (voice)
Jeff Bennett
Salesman (voice)
Kath Soucie
Animal Control Receptionist (voice)
Clint Howard
Balloon Man (voice)
