当臭名昭著的尿布黑手党劫持特罗马维尔特殊学校时，只有毒魔和他病态肥胖的伙伴拉达斯才能拯救特罗马维尔。
David Mattey
Toxic Avenger / Noxious Offender
Debbie Rochon
Ms. Weiner
Clyde Lewis
Toxie (voice)
Heidi Sjursen
Sarah / Claire
Ron Jeremy
Mayor Goldberg
Tom Fulp
Painter
Paul Kyrmse
Sgt. Kabukiman / Evil Kabukiman
Stan Lee
Prologue / Epilogue Narrator (voice)
Joe Fleishaker
Chester / Lardass
Dan Snow
Sgt. Kazinski
Michael Budinger
Tito
Lisa Terezakis
Sweetie Honey
Barry Brisco
Pompey
Corey Feldman
Sarah's Gynecologist
