美国刚刚从法国收购了路易斯安那。 由刘易斯和克拉克（Lewis and Clark）率领的探险队被派去调查该领土，并前往以前没有白人的地方。 他们能否在萨卡哈维亚的帮助下克服危险？
Fred MacMurray
Cpt. Meriwether Lewis
Charlton Heston
Lt. William Clark
Donna Reed
Sacajawea
Barbara Hale
Julia Hancock
William Demarest
Sgt. Gass
Alan Reed
Charbonneau
Eduardo Noriega
Chief Cameahwait
Larry Pennell
Wild Eagle
Herbert Heyes
President Thomas Jefferson
Lester Matthews
Mr. Hancock
Argentina Brunetti
Shoshone Woman (uncredited)
Julia Montoya
Crow Woman (uncredited)
Ralph Moody
Chief Le Borgne (uncredited)
William Phipps
Night Camp Sentry (uncredited)
