Paul Reubens
Pee-wee Herman
Penelope Ann Miller
Winnie
Kris Kristofferson
Mace Montana
Valeria Golino
Gina Piccolapupula
Benicio del Toro
Duke the Dog-Faced Boy
Wayne White
Vance the Pig (voice)
Susan Tyrrell
Midge Montana
Albert Henderson
Mr. Ryan
Jack Murdock
Otis
David Byrd
Deke
Mary Jackson
Mrs. Dill
Frances Bay
Mrs. Haynes
Leo Gordon
Joe the Blacksmith (as Leo V. Gordon)
Anne Seymour
Pearl
