O investigador caça seu arquiinimigo, Professor Moriarty, que está planejando o crime do século.
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Dr. Watson
Ida Lupino
Ann Brandon
Alan Marshal
Jerrold Hunter
Terry Kilburn
Billy
George Zucco
Professor Moriarty
Henry Stephenson
Sir Ronald Ramsgate
E. E. Clive
Inspector Bristol
Arthur Hohl
Henchman Bassick
May Beatty
Mrs. Jameson, Brandon Housekeeper
Peter Willes
Lloyd Brandon
Mary Gordon
Mrs. Hudson
Holmes Herbert
Justice of the Court
George Regas
Henchman Mateo
