De waargebeurde expeditie van Lewis en Clark wordt gevolgd.
Fred MacMurray
Cpt. Meriwether Lewis
Charlton Heston
Lt. William Clark
Donna Reed
Sacajawea
Barbara Hale
Julia Hancock
William Demarest
Sgt. Gass
Alan Reed
Charbonneau
Eduardo Noriega
Chief Cameahwait
Larry Pennell
Wild Eagle
Herbert Heyes
President Thomas Jefferson
Lester Matthews
Mr. Hancock
Argentina Brunetti
Shoshone Woman (uncredited)
Julia Montoya
Crow Woman (uncredited)
Ralph Moody
Chief Le Borgne (uncredited)
William Phipps
Night Camp Sentry (uncredited)
