宇宙に現れた謎の「モノリス」の調査を進める一方で、2人の宇宙飛行士は、乗り込んだ宇宙船の人工知能システムに手を焼き始める。
Keir Dullea
Dr. David Bowman
Gary Lockwood
Dr. Frank Poole
William Sylvester
Dr. Heywood Floyd
Douglas Rain
HAL 9000 (voice)
Daniel Richter
Moonwatcher
Leonard Rossiter
Dr. Andrei Smyslov
Margaret Tyzack
Elena
Robert Beatty
Dr. Ralph Halvorsen
Sean Sullivan
Dr. Roy Michaels
Frank W. Miller
Mission Controller (voice)
Bill Weston
Astronaut
Ed Bishop
Aries-1B Lunar Shuttle Captain
Glenn Beck
Alan Gifford
Poole's Father
