Et t-virusudbrud i San Francisco fører til Alcatraz-øen, hvor et nyt onde har taget ophold.
Matthew Mercer
Leon Scott Kennedy (voice)
Nicole Tompkins
Jill Valentine (voice)
Kevin Dorman
Chris Redfield (voice)
Stephanie Panisello
Claire Redfield (voice)
Erin Cahill
Rebecca Chambers (voice)
Salli Saffioti
Ingrid Hunnigan (voice)
Daman Mills
Dylan Blake (voice)
Lucien Dodge
JJ (voice)
Cristina Valenzuela
Maria Gomez (voice)
Frank Todaro
Antonio Taylor (voice)
Alejandro Saab
Reporting Student (voice)
Bob Carter
SWAT Captain (voice)
Isaac Robinson-Smith
William (voice)
Bill Butts
Additional Voices (voice)
